We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Malignant cells showed weak to moderate nuclear staining. Several renal cancers were negative.
GENE INFORMATION
Gene name
RNF40 (HGNC Symbol)
Synonyms
BRE1B, KIAA0661, RBP95, STARING
Description
Ring finger protein 40, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]