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RNF40

GENERAL INFORMATION

Gene name

 RNF40

Gene description

 Ring finger protein 40, E3 ubiquitin protein ligase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly nuclear expression at variable levels in essentially all cell types, except in adipose cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA041330
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RNF40 (HGNC Symbol)

Synonyms

 BRE1B, KIAA0661, RBP95, STARING

Description

 Ring finger protein 40, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 30761745 - 30776307

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103549 (version 83.38)

Entrez gene

 9810

UniProt

 O75150 (UniProt - Evidence at protein level)

neXtProt

 NX_O75150

Antibodypedia

 RNF40 antibodies

PROTEIN BROWSER
RNF40-001
RNF40-009
RNF40-010
RNF40-011
RNF40-012
RNF40-013
RNF40-015
RNF40-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF40-001
ENSP00000325677
ENST00000324685
O75150 [Direct mapping]
E3 ubiquitin-protein ligase BRE1B
A0A024QZG0 [Target identity:100%; Query identity:100%]
Ring finger protein 40, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0003730 [mRNA 3'-UTR binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0010390 [histone monoubiquitination]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0017075 [syntaxin-1 binding]
GO:0019898 [extrinsic component of membrane]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032403 [protein complex binding]
GO:0033503 [HULC complex]
GO:0033523 [histone H2B ubiquitination]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0043434 [response to peptide hormone]
GO:0043679 [axon terminus]
GO:0046872 [metal ion binding]
GO:1900364 [negative regulation of mRNA polyadenylation]
GO:1901800 [positive regulation of proteasomal protein catabolic process]
GO:1902916 [positive regulation of protein polyubiquitination]
GO:2001168 [positive regulation of histone H2B ubiquitination]
Show all
 1001 aa
113.7 kDa 		No 0
RNF40-009
ENSP00000350563
ENST00000357890
O75150 [Direct mapping]
E3 ubiquitin-protein ligase BRE1B
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0003730 [mRNA 3'-UTR binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008270 [zinc ion binding]
GO:0010390 [histone monoubiquitination]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033503 [HULC complex]
GO:0033523 [histone H2B ubiquitination]
GO:0042803 [protein homodimerization activity]
GO:0043005 [neuron projection]
GO:0046872 [metal ion binding]
GO:1900364 [negative regulation of mRNA polyadenylation]
GO:2001168 [positive regulation of histone H2B ubiquitination]
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 901 aa
102.1 kDa 		No 0
RNF40-010
ENSP00000456538
ENST00000565995
H3BS50 [Direct mapping]
E3 ubiquitin-protein ligase BRE1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 174 aa
20 kDa 		No 0
RNF40-011
ENSP00000455180
ENST00000563683
H3BP71 [Direct mapping]
E3 ubiquitin-protein ligase BRE1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 961 aa
109 kDa 		No 0
RNF40-012
ENSP00000455678
ENST00000563909
H3BQ99 [Direct mapping]
E3 ubiquitin-protein ligase BRE1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 111 aa
12.5 kDa 		No 0
RNF40-013
ENSP00000457697
ENST00000566811
H3BUL6 [Direct mapping]
E3 ubiquitin-protein ligase BRE1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 129 aa
14.4 kDa 		No 0
RNF40-015
ENSP00000460142
ENST00000565931
I3L332 [Direct mapping]
E3 ubiquitin-protein ligase BRE1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
15.8 kDa 		No 0
RNF40-019
ENSP00000477937
ENST00000567365
A0A087WTK2 [Direct mapping]
E3 ubiquitin-protein ligase BRE1B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 177 aa
20.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.