Cell atlas - AAGAB - The Human Protein Atlas

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AAGAB

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear speckles

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	AAGAB
Gene description	Alpha- and gamma-adaptin binding protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA040174
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nuclear speckles.

Main location

Nuclear speckles (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040174	A-431	Nuclear speckles
	HPA040174	A-431	Cytosol
	HPA040174	U-2 OS	Nuclear speckles
	HPA040174	U-2 OS	Cytosol
	HPA040174	U-251 MG	Nuclear speckles
	HPA040174	U-251 MG	Cytosol

GENE INFORMATION
Gene name	AAGAB (HGNC Symbol)
Synonyms	FLJ11506, p34
Description	Alpha- and gamma-adaptin binding protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	15
Cytoband	q23
Chromosome location (bp)	67201033 - 67255195
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103591 (version 83.38)
Entrez gene	79719
UniProt	Q6PD74 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PD74
Antibodypedia	AAGAB antibodies

PROTEIN BROWSER

AAGAB-001	AAGAB-002	AAGAB-003	AAGAB-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AAGAB-001 ENSP00000261880 ENST00000261880	Q6PD74 [Direct mapping] Alpha- and gamma-adaptin-binding protein p34 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0015031 [protein transport] Show all	315 aa 34.6 kDa	No	0
AAGAB-002 ENSP00000440735 ENST00000542650	Q6PD74 [Direct mapping] Alpha- and gamma-adaptin-binding protein p34 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0015031 [protein transport] Show all	206 aa 22.7 kDa	No	0
AAGAB-003 ENSP00000453263 ENST00000561452	Q6PD74 [Direct mapping] Alpha- and gamma-adaptin-binding protein p34 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0015031 [protein transport] Show all	206 aa 22.7 kDa	No	0
AAGAB-005 ENSP00000453059 ENST00000560362	H0YL49 [Direct mapping] Alpha- and gamma-adaptin-binding protein p34 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.