Cell atlas - HERC1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

HERC1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	HERC1
Gene description	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	HERC1 (HGNC Symbol)
Synonyms	p532, p619
Description	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HGNC Symbol)
Entrez gene summary	This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	63608618 - 63833942
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103657 (version 83.38)
Entrez gene	8925
UniProt	Q15751 (UniProt - Evidence at protein level)
neXtProt	NX_Q15751
Antibodypedia	HERC1 antibodies

PROTEIN BROWSER

HERC1-001	HERC1-003	HERC1-004	HERC1-005	HERC1-014	HERC1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HERC1-001 ENSP00000390158 ENST00000443617	Q15751 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 A0A024R5W0 [Target identity:100%; Query identity:100%] Hect (Homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0006810 [transport] GO:0010507 [negative regulation of autophagy] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0021702 [cerebellar Purkinje cell differentiation] GO:0031175 [neuron projection development] GO:0043547 [positive regulation of GTPase activity] GO:0050885 [neuromuscular process controlling balance] Show all	4861 aa 532.2 kDa	No	1
HERC1-003 ENSP00000453937 ENST00000561400	H0YNB1 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		691 aa 76 kDa	No	0
HERC1-004 ENSP00000453010 ENST00000560316	H0YL07 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 2.4 kDa	No	0
HERC1-005 ENSP00000453086 ENST00000558532	H0YL74 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17 kDa	No	0
HERC1-014 ENSP00000452654 ENST00000559715	H0YK45 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 17.9 kDa	No	0
HERC1-015 ENSP00000452969 ENST00000560462	H0YKW7 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 16.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.