Tissue expression of HERC1 - Summary - The Human Protein Atlas

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HERC1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	HERC1
Gene description	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Expression in a subset of immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA049749
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	HERC1 (HGNC Symbol)
Synonyms	p532, p619
Description	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HGNC Symbol)
Entrez gene summary	This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	63608618 - 63833942
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103657 (version 83.38)
Entrez gene	8925
UniProt	Q15751 (UniProt - Evidence at protein level)
neXtProt	NX_Q15751
Antibodypedia	HERC1 antibodies

PROTEIN BROWSER

HERC1-001	HERC1-003	HERC1-004	HERC1-005	HERC1-014	HERC1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HERC1-001 ENSP00000390158 ENST00000443617	Q15751 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 A0A024R5W0 [Target identity:100%; Query identity:100%] Hect (Homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0006810 [transport] GO:0010507 [negative regulation of autophagy] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0021702 [cerebellar Purkinje cell differentiation] GO:0031175 [neuron projection development] GO:0043547 [positive regulation of GTPase activity] GO:0050885 [neuromuscular process controlling balance] Show all	4861 aa 532.2 kDa	No	1
HERC1-003 ENSP00000453937 ENST00000561400	H0YNB1 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		691 aa 76 kDa	No	0
HERC1-004 ENSP00000453010 ENST00000560316	H0YL07 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 2.4 kDa	No	0
HERC1-005 ENSP00000453086 ENST00000558532	H0YL74 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17 kDa	No	0
HERC1-014 ENSP00000452654 ENST00000559715	H0YK45 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 17.9 kDa	No	0
HERC1-015 ENSP00000452969 ENST00000560462	H0YKW7 [Direct mapping] Probable E3 ubiquitin-protein ligase HERC1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 16.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.