Cell atlas - RPAP1 - The Human Protein Atlas

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RPAP1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RPAP1
Gene description	RNA polymerase II associated protein 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041739
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041739	A-431	Nucleoplasm
	HPA041739	A-431	Cytosol
	HPA041739	U-2 OS	Nucleoplasm
	HPA041739	U-2 OS	Cytosol
	HPA041739	U-251 MG	Nucleoplasm
	HPA041739	U-251 MG	Cytosol

GENE INFORMATION
Gene name	RPAP1 (HGNC Symbol)
Synonyms	DKFZP727M111, FLJ12732, KIAA1403, MGC858
Description	RNA polymerase II associated protein 1 (HGNC Symbol)
Entrez gene summary	This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	41517176 - 41544269
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103932 (version 83.38)
Entrez gene	26015
UniProt	Q9BWH6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWH6
Antibodypedia	RPAP1 antibodies

PROTEIN BROWSER

RPAP1-001	RPAP1-004	RPAP1-008	RPAP1-010	RPAP1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPAP1-001 ENSP00000306123 ENST00000304330	Q9BWH6 [Direct mapping] RNA polymerase II-associated protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] Show all	1393 aa 152.8 kDa	No	1
RPAP1-004 ENSP00000456207 ENST00000561603	H3BRE8 [Direct mapping] RNA polymerase II-associated protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] Show all	1128 aa 123.1 kDa	No	1
RPAP1-008 ENSP00000455527 ENST00000566863	H3BPY8 [Direct mapping] RNA polymerase II-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] Show all	128 aa 13.8 kDa	No	0
RPAP1-010 ENSP00000455381 ENST00000567866	H3BPM3 [Direct mapping] RNA polymerase II-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] Show all	180 aa 19.3 kDa	No	0
RPAP1-012 ENSP00000457203 ENST00000565035	H3BTJ6 [Direct mapping] RNA polymerase II-associated protein 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] Show all	200 aa 22 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.