Expression of ATP8B4 in cancer - Summary

CANCER ATLAS

Gene description

ATPase, class I, type 8B, member 4

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040254

GENE INFORMATION
Gene name	ATP8B4 (HGNC Symbol)
Synonyms	ATPIM, KIAA1939
Description	ATPase, class I, type 8B, member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	49858238 - 50182817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104043 (version 83.38)
Entrez gene	79895
UniProt	Q8TF62 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TF62
Antibodypedia	ATP8B4 antibodies

PROTEIN BROWSER

ATP8B4-001	ATP8B4-009	ATP8B4-016	ATP8B4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP8B4-001 ENSP00000453169 ENST00000559829	Q8TF62 [Direct mapping] Probable phospholipid-transporting ATPase IM Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] Show all	1192 aa 135.9 kDa	No	>9
ATP8B4-009 ENSP00000453539 ENST00000558829	H0YMB5 [Direct mapping] Probable phospholipid-transporting ATPase IM Show all	Predicted intracellular proteins Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	53 aa 6.6 kDa	No	0
ATP8B4-016 ENSP00000453143 ENST00000558024	H0YLC1 [Direct mapping] Probable phospholipid-transporting ATPase IM Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	95 aa 10.8 kDa	Yes	1
ATP8B4-201 ENSP00000284509 ENST00000284509	Q8TF62 [Direct mapping] Probable phospholipid-transporting ATPase IM Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] Show all	1192 aa 135.9 kDa	No	>9