Cell atlas - ATP8B4 - The Human Protein Atlas

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ATP8B4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ATP8B4
Gene description	ATPase, class I, type 8B, member 4
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm & vesicles.
RNA cell category	Cell line enhanced (U-937, HMC-1, THP-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040254
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-937, HMC-1, THP-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040254	SiHa	Nucleoplasm
			Vesicles
			Cytosol
	HPA040254	U-2 OS	Nucleoplasm
	HPA040254	U-2 OS	Vesicles
	HPA040254	U-251 MG	Nucleoplasm
	HPA040254	U-251 MG	Vesicles

GENE INFORMATION
Gene name	ATP8B4 (HGNC Symbol)
Synonyms	ATPIM, KIAA1939
Description	ATPase, class I, type 8B, member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cation transport ATPase (P-type) family and type IV subfamily. The encoded protein is involved in phospholipid transport in the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	49858238 - 50182817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104043 (version 83.38)
Entrez gene	79895
UniProt	Q8TF62 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TF62
Antibodypedia	ATP8B4 antibodies

PROTEIN BROWSER

ATP8B4-001	ATP8B4-009	ATP8B4-016	ATP8B4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP8B4-001 ENSP00000453169 ENST00000559829	Q8TF62 [Direct mapping] Probable phospholipid-transporting ATPase IM Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] Show all	1192 aa 135.9 kDa	No	>9
ATP8B4-009 ENSP00000453539 ENST00000558829	H0YMB5 [Direct mapping] Probable phospholipid-transporting ATPase IM Show all	Predicted intracellular proteins Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	53 aa 6.6 kDa	No	0
ATP8B4-016 ENSP00000453143 ENST00000558024	H0YLC1 [Direct mapping] Probable phospholipid-transporting ATPase IM Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0007030 [Golgi organization] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] Show all	95 aa 10.8 kDa	Yes	1
ATP8B4-201 ENSP00000284509 ENST00000284509	Q8TF62 [Direct mapping] Probable phospholipid-transporting ATPase IM Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0004012 [phospholipid-translocating ATPase activity] GO:0005524 [ATP binding] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007030 [Golgi organization] GO:0008152 [metabolic process] GO:0015914 [phospholipid transport] GO:0016021 [integral component of membrane] GO:0045332 [phospholipid translocation] GO:0046872 [metal ion binding] Show all	1192 aa 135.9 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.