Cell atlas - DMXL2 - The Human Protein Atlas

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DMXL2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	DMXL2
Gene description	Dmx-like 2
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	DMXL2 (HGNC Symbol)
Synonyms	KIAA0856, RC3
Description	Dmx-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	51447711 - 51622833
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104093 (version 83.38)
Entrez gene	23312
UniProt	Q8TDJ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDJ6
Antibodypedia	DMXL2 antibodies

PROTEIN BROWSER

DMXL2-001	DMXL2-003	DMXL2-004	DMXL2-013	DMXL2-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DMXL2-001 ENSP00000251076 ENST00000251076	Q8TDJ6 [Direct mapping] DmX-like protein 2 A0A024R5V2 [Target identity:100%; Query identity:100%] Dmx-like 2, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0008021 [synaptic vesicle] GO:0017137 [Rab GTPase binding] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] Show all	3036 aa 339.6 kDa	No	1
DMXL2-003 ENSP00000400855 ENST00000449909	Q8TDJ6 [Direct mapping] DmX-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0008021 [synaptic vesicle] GO:0017137 [Rab GTPase binding] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] Show all	2400 aa 270.1 kDa	No	1
DMXL2-004 ENSP00000453267 ENST00000560891	H0YLM8 [Direct mapping] DmX-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1183 aa 132.5 kDa	No	1
DMXL2-013 ENSP00000453570 ENST00000559059	H0YME1 [Direct mapping] DmX-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.2 kDa	No	0
DMXL2-014 ENSP00000441858 ENST00000543779	Q8TDJ6 [Direct mapping] DmX-like protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0008021 [synaptic vesicle] GO:0017137 [Rab GTPase binding] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] Show all	3037 aa 339.7 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.