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DMXL2

GENERAL INFORMATION

Gene name

 DMXL2

Gene description

 Dmx-like 2

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039375
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 DMXL2 (HGNC Symbol)

Synonyms

 KIAA0856, RC3

Description

 Dmx-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 51447711 - 51622833

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104093 (version 83.38)

Entrez gene

 23312

UniProt

 Q8TDJ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDJ6

Antibodypedia

 DMXL2 antibodies

PROTEIN BROWSER
DMXL2-001
DMXL2-003
DMXL2-004
DMXL2-013
DMXL2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DMXL2-001
ENSP00000251076
ENST00000251076
Q8TDJ6 [Direct mapping]
DmX-like protein 2
A0A024R5V2 [Target identity:100%; Query identity:100%]
Dmx-like 2, isoform CRA_c
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0008021 [synaptic vesicle]
GO:0017137 [Rab GTPase binding]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
Show all
 3036 aa
339.6 kDa 		No 1
DMXL2-003
ENSP00000400855
ENST00000449909
Q8TDJ6 [Direct mapping]
DmX-like protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0008021 [synaptic vesicle]
GO:0017137 [Rab GTPase binding]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
Show all
 2400 aa
270.1 kDa 		No 1
DMXL2-004
ENSP00000453267
ENST00000560891
H0YLM8 [Direct mapping]
DmX-like protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1183 aa
132.5 kDa 		No 1
DMXL2-013
ENSP00000453570
ENST00000559059
H0YME1 [Direct mapping]
DmX-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.2 kDa 		No 0
DMXL2-014
ENSP00000441858
ENST00000543779
Q8TDJ6 [Direct mapping]
DmX-like protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0008021 [synaptic vesicle]
GO:0017137 [Rab GTPase binding]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
Show all
 3037 aa
339.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.