Expression of EIF3J in cancer - Summary

CANCER ATLAS

Gene description

Eukaryotic translation initiation factor 3, subunit J

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA050977

GENE INFORMATION
Gene name	EIF3J (HGNC Symbol)
Synonyms	eIF3-alpha, eIF3-p35, eIF3j, EIF3S1
Description	Eukaryotic translation initiation factor 3, subunit J (HGNC Symbol)
Entrez gene summary	This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	44537057 - 44563029
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104131 (version 83.38)
Entrez gene	8669
UniProt	O75822 (UniProt - Evidence at protein level)
neXtProt	NX_O75822
Antibodypedia	EIF3J antibodies

PROTEIN BROWSER

EIF3J-001	EIF3J-002	EIF3J-003	EIF3J-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF3J-001 ENSP00000261868 ENST00000261868	O75822 [Direct mapping] Eukaryotic translation initiation factor 3 subunit J A0A024R5S5 [Target identity:100%; Query identity:100%] Eukaryotic translation initiation factor 3 subunit J Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001731 [formation of translation preinitiation complex] GO:0002181 [cytoplasmic translation] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005852 [eukaryotic translation initiation factor 3 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010467 [gene expression] GO:0016282 [eukaryotic 43S preinitiation complex] GO:0033290 [eukaryotic 48S preinitiation complex] GO:0044267 [cellular protein metabolic process] Show all	258 aa 29.1 kDa	No	0
EIF3J-002 ENSP00000440221 ENST00000535391	O75822 [Direct mapping] Eukaryotic translation initiation factor 3 subunit J Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001731 [formation of translation preinitiation complex] GO:0002181 [cytoplasmic translation] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005852 [eukaryotic translation initiation factor 3 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010467 [gene expression] GO:0016282 [eukaryotic 43S preinitiation complex] GO:0033290 [eukaryotic 48S preinitiation complex] GO:0044267 [cellular protein metabolic process] Show all	204 aa 22.9 kDa	No	0
EIF3J-003 ENSP00000414548 ENST00000424492	O75822 [Direct mapping] Eukaryotic translation initiation factor 3 subunit J Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001731 [formation of translation preinitiation complex] GO:0002181 [cytoplasmic translation] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005852 [eukaryotic translation initiation factor 3 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0010467 [gene expression] GO:0016282 [eukaryotic 43S preinitiation complex] GO:0033290 [eukaryotic 48S preinitiation complex] GO:0044267 [cellular protein metabolic process] Show all	209 aa 23 kDa	No	0
EIF3J-004 ENSP00000443563 ENST00000536248	H0YGJ7 [Direct mapping] Eukaryotic translation initiation factor 3 subunit J Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002181 [cytoplasmic translation] GO:0003743 [translation initiation factor activity] GO:0005737 [cytoplasm] GO:0005852 [eukaryotic translation initiation factor 3 complex] GO:0006413 [translational initiation] Show all	106 aa 12 kDa	No	0