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VPS18

CANCER ATLAS

Gene description

 Vacuolar protein sorting 18 homolog (S. cerevisiae)

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA040701

GENE INFORMATION

Gene name

 VPS18 (HGNC Symbol)

Synonyms

 KIAA1475, PEP3

Description

 Vacuolar protein sorting 18 homolog (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

 Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 40894430 - 40903975

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104142 (version 83.38)

Entrez gene

 57617

UniProt

 Q9P253 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P253

Antibodypedia

 VPS18 antibodies

PROTEIN BROWSER
VPS18-001
VPS18-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS18-001
ENSP00000220509
ENST00000220509
Q9P253 [Direct mapping]
Vacuolar protein sorting-associated protein 18 homolog
A0A024R9R3 [Target identity:100%; Query identity:100%]
Vacuolar protein sorting protein 18, isoform CRA_d
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005884 [actin filament]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006914 [autophagy]
GO:0007032 [endosome organization]
GO:0007040 [lysosome organization]
GO:0008333 [endosome to lysosome transport]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0030123 [AP-3 adaptor complex]
GO:0030136 [clathrin-coated vesicle]
GO:0030674 [protein binding, bridging]
GO:0030897 [HOPS complex]
GO:0031902 [late endosome membrane]
GO:0033263 [CORVET complex]
GO:0035542 [regulation of SNARE complex assembly]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
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 973 aa
110.2 kDa 		No 0
VPS18-004
ENSP00000453555
ENST00000558474
H0YMC9 [Direct mapping]
Vacuolar protein sorting-associated protein 18 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005623 [cell]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0030674 [protein binding, bridging]
GO:0035542 [regulation of SNARE complex assembly]
Show all
 121 aa
13.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.