Expression of SLC30A4 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 30 (zinc transporter), member 4

Protein class

Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018178

GENE INFORMATION
Gene name	SLC30A4 (HGNC Symbol)
Synonyms	ZNT4
Description	Solute carrier family 30 (zinc transporter), member 4 (HGNC Symbol)
Entrez gene summary	Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	45479611 - 45522807
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104154 (version 83.38)
Entrez gene	7782
UniProt	O14863 (UniProt - Evidence at transcript level)
neXtProt	NX_O14863
Antibodypedia	SLC30A4 antibodies

PROTEIN BROWSER

SLC30A4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC30A4-001 ENSP00000261867 ENST00000261867	O14863 [Direct mapping] Zinc transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0006812 [cation transport] GO:0008324 [cation transmembrane transporter activity] GO:0009636 [response to toxic substance] GO:0010043 [response to zinc ion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0031902 [late endosome membrane] GO:0055069 [zinc ion homeostasis] GO:0055085 [transmembrane transport] GO:0061088 [regulation of sequestering of zinc ion] GO:0071577 [zinc II ion transmembrane transport] Show all	429 aa 47.5 kDa	No	6