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SLC30A4

GENERAL INFORMATION

Gene name

 SLC30A4

Gene description

 Solute carrier family 30 (zinc transporter), member 4

Protein class

 Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (prostate)
GTEx:Tissue enhanced (prostate)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA018178
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC30A4 (HGNC Symbol)

Synonyms

 ZNT4

Description

 Solute carrier family 30 (zinc transporter), member 4 (HGNC Symbol)

Entrez gene summary

 Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 45479611 - 45522807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104154 (version 83.38)

Entrez gene

 7782

UniProt

 O14863 (UniProt - Evidence at transcript level)

neXtProt

 NX_O14863

Antibodypedia

 SLC30A4 antibodies

PROTEIN BROWSER
SLC30A4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC30A4-001
ENSP00000261867
ENST00000261867
O14863 [Direct mapping]
Zinc transporter 4
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005770 [late endosome]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0009636 [response to toxic substance]
GO:0010043 [response to zinc ion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0031902 [late endosome membrane]
GO:0055069 [zinc ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0061088 [regulation of sequestering of zinc ion]
GO:0071577 [zinc II ion transmembrane transport]
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 429 aa
47.5 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.