Expression of DECR1 in cancer - Summary

CANCER ATLAS

Gene description

2,4-dienoyl CoA reductase 1, mitochondrial

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA023160	HPA023162	HPA023238

GENE INFORMATION
Gene name	DECR1 (HGNC Symbol)
Synonyms	DECR, SDR18C1
Description	2,4-dienoyl CoA reductase 1, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q21.3
Chromosome location (bp)	90001405 - 90052092
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104325 (version 83.38)
Entrez gene	1666
UniProt	Q16698 (UniProt - Evidence at protein level)
neXtProt	NX_Q16698
Antibodypedia	DECR1 antibodies

PROTEIN BROWSER

DECR1-001	DECR1-003	DECR1-008	DECR1-013	DECR1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DECR1-001 ENSP00000220764 ENST00000220764	Q16698 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial A0A024R9D7 [Target identity:100%; Query identity:100%] 2,4-dienoyl CoA reductase 1, mitochondrial, isoform CRA_b Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008670 [2,4-dienoyl-CoA reductase (NADPH) activity] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051289 [protein homotetramerization] GO:0070062 [extracellular exosome] GO:0070402 [NADPH binding] Show all	335 aa 36.1 kDa	No	0
DECR1-003 ENSP00000429779 ENST00000522161	Q16698 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008670 [2,4-dienoyl-CoA reductase (NADPH) activity] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051289 [protein homotetramerization] GO:0070062 [extracellular exosome] GO:0070402 [NADPH binding] Show all	326 aa 35 kDa	No	0
DECR1-008 ENSP00000430561 ENST00000519410	E5RJG7 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	181 aa 19.3 kDa	No	0
DECR1-013 ENSP00000427936 ENST00000517761	E5RFV2 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	205 aa 21.8 kDa	No	0
DECR1-014 ENSP00000429096 ENST00000520227	E5RJD2 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	151 aa 15.9 kDa	No	0