Cell atlas - DECR1 - The Human Protein Atlas

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DECR1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria

Human cell
	Cytosol
	Mitochondria

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GENERAL INFORMATION
Gene name	DECR1
Gene description	2,4-dienoyl CoA reductase 1, mitochondrial
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Cytosol (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA023162
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the cytosol.

Main location

Mitochondria (supported)

Additional location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023162	A-431	Nucleoplasm	Spatial
			Mitochondria	Spatial
			Cytosol	Spatial
	HPA023162	U-2 OS	Mitochondria
	HPA023162	U-2 OS	Cytosol
	HPA023162	U-251 MG	Mitochondria
	HPA023162	U-251 MG	Cytosol

GENE INFORMATION
Gene name	DECR1 (HGNC Symbol)
Synonyms	DECR, SDR18C1
Description	2,4-dienoyl CoA reductase 1, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q21.3
Chromosome location (bp)	90001405 - 90052092
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104325 (version 83.38)
Entrez gene	1666
UniProt	Q16698 (UniProt - Evidence at protein level)
neXtProt	NX_Q16698
Antibodypedia	DECR1 antibodies

PROTEIN BROWSER

DECR1-001	DECR1-003	DECR1-008	DECR1-013	DECR1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DECR1-001 ENSP00000220764 ENST00000220764	Q16698 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial A0A024R9D7 [Target identity:100%; Query identity:100%] 2,4-dienoyl CoA reductase 1, mitochondrial, isoform CRA_b Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008670 [2,4-dienoyl-CoA reductase (NADPH) activity] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051289 [protein homotetramerization] GO:0070062 [extracellular exosome] GO:0070402 [NADPH binding] Show all	335 aa 36.1 kDa	No	0
DECR1-003 ENSP00000429779 ENST00000522161	Q16698 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008670 [2,4-dienoyl-CoA reductase (NADPH) activity] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0051289 [protein homotetramerization] GO:0070062 [extracellular exosome] GO:0070402 [NADPH binding] Show all	326 aa 35 kDa	No	0
DECR1-008 ENSP00000430561 ENST00000519410	E5RJG7 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	181 aa 19.3 kDa	No	0
DECR1-013 ENSP00000427936 ENST00000517761	E5RFV2 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	205 aa 21.8 kDa	No	0
DECR1-014 ENSP00000429096 ENST00000520227	E5RJD2 [Direct mapping] 2,4-dienoyl-CoA reductase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	151 aa 15.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.