Expression of PLAT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Plasminogen activator, tissue

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003412	CAB009335

GENE INFORMATION
Gene name	PLAT
Synonyms
Description	Plasminogen activator, tissue (HGNC Symbol)
Entrez gene summary	This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42175233 - 42207724
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104368 (version 83.38)
Entrez gene	5327
UniProt	P00750 (UniProt - Evidence at protein level)
neXtProt	NX_P00750
Antibodypedia	PLAT antibodies

PROTEIN BROWSER

PLAT-001	PLAT-002	PLAT-003	PLAT-004	PLAT-005	PLAT-006	PLAT-011	PLAT-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLAT-001 ENSP00000220809 ENST00000220809	P00750 [Direct mapping] Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0001948 [glycoprotein binding] GO:0004252 [serine-type endopeptidase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0014909 [smooth muscle cell migration] GO:0030141 [secretory granule] GO:0031639 [plasminogen activation] GO:0042730 [fibrinolysis] GO:0045177 [apical part of cell] GO:0045861 [negative regulation of proteolysis] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0051219 [phosphoprotein binding] GO:0070062 [extracellular exosome] Show all	562 aa 62.9 kDa	Yes	0
PLAT-002 ENSP00000270188 ENST00000352041	P00750 [Direct mapping] Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0004252 [serine-type endopeptidase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0031639 [plasminogen activation] GO:0042730 [fibrinolysis] GO:0045861 [negative regulation of proteolysis] GO:0051219 [phosphoprotein binding] GO:0070062 [extracellular exosome] Show all	516 aa 57.4 kDa	Yes	0
PLAT-003 ENSP00000392045 ENST00000429089	P00750 [Direct mapping] Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0004252 [serine-type endopeptidase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0031639 [plasminogen activation] GO:0042730 [fibrinolysis] GO:0045861 [negative regulation of proteolysis] GO:0051219 [phosphoprotein binding] GO:0070062 [extracellular exosome] Show all	562 aa 62.9 kDa	Yes	0
PLAT-004 ENSP00000429401 ENST00000524009	B4DN26 [Direct mapping] Tissue-type plasminogen activator; cDNA FLJ59355, highly similar to Tissue-type plasminogen activator (EC 3.4.21.68) Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	473 aa 53 kDa	Yes	0
PLAT-005 ENSP00000428886 ENST00000519510	E7ESF4 [Direct mapping] Tissue-type plasminogen activator Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	499 aa 55.9 kDa	Yes	0
PLAT-006 ENSP00000407861 ENST00000429710	B4DNJ1 [Direct mapping] Tissue-type plasminogen activator; cDNA FLJ59358, highly similar to Tissue-type plasminogen activator (EC 3.4.21.68) Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0031639 [plasminogen activation] Show all	436 aa 49.1 kDa	Yes	0
PLAT-011 ENSP00000429801 ENST00000521694	E5RHG4 [Direct mapping] Tissue-type plasminogen activator Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	157 aa 17.7 kDa	Yes	0
PLAT-012 ENSP00000428797 ENST00000520523	E5RGA1 [Direct mapping] Tissue-type plasminogen activator Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	178 aa 20.1 kDa	Yes	0