Tissue expression of STMN2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	STMN2
Gene description	Stathmin 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Tissue enhanced (cerebellum, hypothalamus, cerebral cortex)
FANTOM5:	Group enriched (cerebellum, brain, hippocampus, caudate)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, hypothalamus, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, brain, hippocampus, caudate)

GENE INFORMATION
Gene name	STMN2 (HGNC Symbol)
Synonyms	SCG10, SCGN10
Description	Stathmin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]
Chromosome	8
Cytoband	q21.13
Chromosome location (bp)	79610814 - 79666175
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104435 (version 83.38)
Entrez gene	11075
UniProt	Q93045 (UniProt - Evidence at protein level)
neXtProt	NX_Q93045
Antibodypedia	STMN2 antibodies

PROTEIN BROWSER

STMN2-001	STMN2-007	STMN2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STMN2-001 ENSP00000220876 ENST00000220876	Q93045 [Direct mapping] Stathmin-2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0007019 [microtubule depolymerization] GO:0007026 [negative regulation of microtubule depolymerization] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031110 [regulation of microtubule polymerization or depolymerization] GO:0031115 [negative regulation of microtubule polymerization] GO:0031117 [positive regulation of microtubule depolymerization] GO:0031175 [neuron projection development] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0048306 [calcium-dependent protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:1990090 [cellular response to nerve growth factor stimulus] Show all	179 aa 20.8 kDa	No	0
STMN2-007 ENSP00000430102 ENST00000518491	E5RGX5 [Direct mapping] Stathmin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007019 [microtubule depolymerization] GO:0015631 [tubulin binding] GO:0031110 [regulation of microtubule polymerization or depolymerization] GO:0031175 [neuron projection development] Show all	168 aa 19.6 kDa	No	0
STMN2-008 ENSP00000429243 ENST00000518111	Q93045 [Direct mapping] Stathmin-2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0007019 [microtubule depolymerization] GO:0007026 [negative regulation of microtubule depolymerization] GO:0010976 [positive regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031110 [regulation of microtubule polymerization or depolymerization] GO:0031115 [negative regulation of microtubule polymerization] GO:0031117 [positive regulation of microtubule depolymerization] GO:0031175 [neuron projection development] GO:0031982 [vesicle] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0048306 [calcium-dependent protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:1990090 [cellular response to nerve growth factor stimulus] Show all	187 aa 21.8 kDa	No	0