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Weak to moderate cytoplasmic staining in several cases of cancer tissues. Virtually no staining in prostate, cervical, thyroid, testis, liver cancers and in malignant carcinoids, gliomas and melanomas.
Most cancer tissues were negative. A few cases of most cancers showed weak cytoplasmic staining.
GENE INFORMATION
Gene name
DCTN6 (HGNC Symbol)
Synonyms
WS-3
Description
Dynactin 6 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
