Cell atlas - DCTN6 - The Human Protein Atlas

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DCTN6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Plasma membrane

Human cell
	Cytosol
	Nucleoli
	Plasma Membrane

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GENERAL INFORMATION
Gene name	DCTN6
Gene description	Dynactin 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli & cytosol. In addition localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported), Cytosol (supported)
Additional location	In addition localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA024049 , HPA024558
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli & cytosol. In addition localized to the plasma membrane.

Main location

Nucleoli (supported), Cytosol (supported)

Additional location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA024049	A-431	Nucleoli fibrillar center
		Plasma membrane
		Cell Junctions
		Cytosol
HPA024049	U-2 OS	Nucleoli
HPA024049	U-2 OS	Cytosol
HPA024049	U-251 MG	Nucleoli
		Plasma membrane
		Cytosol
HPA024558	A-431	No staining
HPA024558	U-2 OS	Cytosol
HPA024558	U-251 MG	No staining

GENE INFORMATION
Gene name	DCTN6 (HGNC Symbol)
Synonyms	WS-3
Description	Dynactin 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p12
Chromosome location (bp)	30156297 - 30183640
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104671 (version 83.38)
Entrez gene	10671
UniProt	O00399 (UniProt - Evidence at protein level)
neXtProt	NX_O00399
Antibodypedia	DCTN6 antibodies

PROTEIN BROWSER

DCTN6-001	DCTN6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCTN6-001 ENSP00000221114 ENST00000221114	O00399 [Direct mapping] Dynactin subunit 6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000777 [condensed chromosome kinetochore] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005869 [dynactin complex] GO:0007052 [mitotic spindle organization] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] Show all	190 aa 20.7 kDa	No	0
DCTN6-003 ENSP00000431017 ENST00000520829	E5RK00 [Direct mapping] Dynactin subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005869 [dynactin complex] Show all	170 aa 18.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.