Expression of TUSC3 in cancer - Summary

CANCER ATLAS

Gene description

Tumor suppressor candidate 3

Protein class

Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Urothelial cancer

STAINING SUMMARY

HPA049851	HPA049974

GENE INFORMATION
Gene name	TUSC3 (HGNC Symbol)
Synonyms	MGC13453, MRT7, N33, OST3A
Description	Tumor suppressor candidate 3 (HGNC Symbol)
Entrez gene summary	This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	15417215 - 15766649
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104723 (version 83.38)
Entrez gene	7991
UniProt	Q13454 (UniProt - Evidence at protein level)
neXtProt	NX_Q13454
Antibodypedia	TUSC3 antibodies

PROTEIN BROWSER

TUSC3-001	TUSC3-004	TUSC3-006	TUSC3-007	TUSC3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUSC3-001 ENSP00000371450 ENST00000382020	Q13454 [Direct mapping] Tumor suppressor candidate 3 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045454 [cell redox homeostasis] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	347 aa 39.6 kDa	Yes	4
TUSC3-004 ENSP00000425777 ENST00000506802	D6RIY7 [Direct mapping] Tumor suppressor candidate 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	314 aa 35.7 kDa	Yes	3
TUSC3-006 ENSP00000423426 ENST00000509380	D6RA37 [Direct mapping] Tumor suppressor candidate 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	289 aa 33.1 kDa	Yes	2
TUSC3-007 ENSP00000424544 ENST00000503731	Q13454 [Direct mapping] Tumor suppressor candidate 3 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045454 [cell redox homeostasis] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	348 aa 39.7 kDa	Yes	4
TUSC3-008 ENSP00000426880 ENST00000511783	A0A0A0MTC2 [Direct mapping] Tumor suppressor candidate 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	302 aa 34.6 kDa	No	4