Cell atlas - TUSC3 - The Human Protein Atlas

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TUSC3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TUSC3
Gene description	Tumor suppressor candidate 3
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TUSC3 (HGNC Symbol)
Synonyms	MGC13453, MRT7, N33, OST3A
Description	Tumor suppressor candidate 3 (HGNC Symbol)
Entrez gene summary	This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	15417215 - 15766649
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104723 (version 83.38)
Entrez gene	7991
UniProt	Q13454 (UniProt - Evidence at protein level)
neXtProt	NX_Q13454
Antibodypedia	TUSC3 antibodies

PROTEIN BROWSER

TUSC3-001	TUSC3-004	TUSC3-006	TUSC3-007	TUSC3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUSC3-001 ENSP00000371450 ENST00000382020	Q13454 [Direct mapping] Tumor suppressor candidate 3 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045454 [cell redox homeostasis] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	347 aa 39.6 kDa	Yes	4
TUSC3-004 ENSP00000425777 ENST00000506802	D6RIY7 [Direct mapping] Tumor suppressor candidate 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	314 aa 35.7 kDa	Yes	3
TUSC3-006 ENSP00000423426 ENST00000509380	D6RA37 [Direct mapping] Tumor suppressor candidate 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	289 aa 33.1 kDa	Yes	2
TUSC3-007 ENSP00000424544 ENST00000503731	Q13454 [Direct mapping] Tumor suppressor candidate 3 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006487 [protein N-linked glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045454 [cell redox homeostasis] GO:0050890 [cognition] GO:0055085 [transmembrane transport] GO:1903830 [magnesium ion transmembrane transport] Show all	348 aa 39.7 kDa	Yes	4
TUSC3-008 ENSP00000426880 ENST00000511783	A0A0A0MTC2 [Direct mapping] Tumor suppressor candidate 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016021 [integral component of membrane] GO:0045454 [cell redox homeostasis] Show all	302 aa 34.6 kDa	No	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.