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ADAM2

GENERAL INFORMATION

Gene name

 ADAM2

Gene description

 ADAM metallopeptidase domain 2

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in spermatids in the seminiferus ducts.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA024621 , HPA026581 , CAB022390
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 ADAM2 (HGNC Symbol)

Synonyms

 CT15, FTNB, PH-30b, PH30

Description

 ADAM metallopeptidase domain 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Chromosome

 8

Cytoband

 p11.22

Chromosome location (bp)

 39743735 - 39838289

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104755 (version 83.38)

Entrez gene

 2515

UniProt

 Q99965 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q99965

Antibodypedia

 ADAM2 antibodies

PROTEIN BROWSER
ADAM2-001
ADAM2-002
ADAM2-003
ADAM2-004
ADAM2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAM2-001
ENSP00000265708
ENST00000265708
Q99965 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 2
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0007338 [single fertilization]
GO:0007339 [binding of sperm to zona pellucida]
GO:0007342 [fusion of sperm to egg plasma membrane]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0030534 [adult behavior]
GO:0032504 [multicellular organism reproduction]
Show all
 735 aa
82.5 kDa 		Yes 1
ADAM2-002
ENSP00000429352
ENST00000521880
B4DWY7 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 2; cDNA FLJ60930, highly similar to ADAM 2 (A disintegrin and metalloproteinase domain 2)
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
 672 aa
75.6 kDa 		Yes 1
ADAM2-003
ENSP00000343854
ENST00000347580
Q99965 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 2
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0007338 [single fertilization]
GO:0007339 [binding of sperm to zona pellucida]
GO:0007342 [fusion of sperm to egg plasma membrane]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0032504 [multicellular organism reproduction]
Show all
 716 aa
80.2 kDa 		Yes 1
ADAM2-004
ENSP00000369182
ENST00000379853
Q6P2G0 [Direct mapping]
ADAM metallopeptidase domain 2 (Fertilin beta), isoform CRA_b; ADAM2 protein; Disintegrin and metalloproteinase domain-containing protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
 579 aa
64.8 kDa 		Yes 1
ADAM2-201
ENSP00000483607
ENST00000622267
B4DWY7 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 2; cDNA FLJ60930, highly similar to ADAM 2 (A disintegrin and metalloproteinase domain 2)
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
 672 aa
75.6 kDa 		Yes 1

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.