Expression of ASAH1 in cancer - Summary

CANCER ATLAS

Gene description

N-acylsphingosine amidohydrolase (acid ceramidase) 1

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA005468

GENE INFORMATION
Gene name	ASAH1 (HGNC Symbol)
Synonyms	AC, ASAH, FLJ21558, PHP32
Description	N-acylsphingosine amidohydrolase (acid ceramidase) 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	18056425 - 18084985
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104763 (version 83.38)
Entrez gene	427
UniProt	Q13510 (UniProt - Evidence at protein level)
neXtProt	NX_Q13510
Antibodypedia	ASAH1 antibodies

PROTEIN BROWSER

ASAH1-001	ASAH1-002	ASAH1-003	ASAH1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASAH1-001 ENSP00000262097 ENST00000262097	Q13510 [Direct mapping] Acid ceramidase Acid ceramidase subunit alpha Acid ceramidase subunit beta Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0006629 [lipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006672 [ceramide metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0017040 [ceramidase activity] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	395 aa 44.7 kDa	Yes	0
ASAH1-002 ENSP00000371152 ENST00000381733	Q13510 [Direct mapping] Acid ceramidase Acid ceramidase subunit alpha Acid ceramidase subunit beta Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0006629 [lipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006672 [ceramide metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0017040 [ceramidase activity] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	411 aa 46.5 kDa	No	0
ASAH1-003 ENSP00000326970 ENST00000314146	Q13510 [Direct mapping] Acid ceramidase Acid ceramidase subunit alpha Acid ceramidase subunit beta Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0006629 [lipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006672 [ceramide metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0017040 [ceramidase activity] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	389 aa 44 kDa	No	0
ASAH1-004 ENSP00000427751 ENST00000520781	E7EMM4 [Direct mapping] Acid ceramidase Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0006629 [lipid metabolic process] Show all	370 aa 41.8 kDa	Yes	0