Expression of DHDH in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Dihydrodiol dehydrogenase (dimeric)

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Ovarian cancer

STAINING SUMMARY

HPA044131

GENE INFORMATION
Gene name	DHDH (HGNC Symbol)
Synonyms	HUM2DD
Description	Dihydrodiol dehydrogenase (dimeric) (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48933682 - 48944969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104808 (version 83.38)
Entrez gene	27294
UniProt	Q9UQ10 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQ10
Antibodypedia	DHDH antibodies

PROTEIN BROWSER

DHDH-001	DHDH-003	DHDH-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHDH-001 ENSP00000221403 ENST00000221403	Q9UQ10 [Direct mapping] Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Show all	GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0008746 [NAD(P)+ transhydrogenase activity] GO:0009055 [electron carrier activity] GO:0016491 [oxidoreductase activity] GO:0042843 [D-xylose catabolic process] GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity] GO:0047837 [D-xylose 1-dehydrogenase (NADP+) activity] GO:0055114 [oxidation-reduction process] Show all	334 aa 36.4 kDa	No	0
DHDH-003 ENSP00000428935 ENST00000523250	E5RFE0 [Direct mapping] Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Show all	Predicted intracellular proteins Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	195 aa 21.4 kDa	No	0
DHDH-004 ENSP00000428672 ENST00000522614	E5RGT8 [Direct mapping] Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Show all	Predicted intracellular proteins Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	242 aa 26.4 kDa	No	0