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DHDH

GENERAL INFORMATION

Gene name

 DHDH

Gene description

 Dihydrodiol dehydrogenase (dimeric)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (small intestine, kidney, duodenum)
GTEx:Tissue enhanced (kidney, small intestine)
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 High cytoplasmic expression in small intestines.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA044131
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Cerebellum
N/A
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, kidney, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 DHDH (HGNC Symbol)

Synonyms

 HUM2DD

Description

 Dihydrodiol dehydrogenase (dimeric) (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 48933682 - 48944969

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104808 (version 83.38)

Entrez gene

 27294

UniProt

 Q9UQ10 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQ10

Antibodypedia

 DHDH antibodies

PROTEIN BROWSER
DHDH-001
DHDH-003
DHDH-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHDH-001
ENSP00000221403
ENST00000221403
Q9UQ10 [Direct mapping]
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
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GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0008746 [NAD(P)+ transhydrogenase activity]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0042843 [D-xylose catabolic process]
GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity]
GO:0047837 [D-xylose 1-dehydrogenase (NADP+) activity]
GO:0055114 [oxidation-reduction process]
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 334 aa
36.4 kDa 		No 0
DHDH-003
ENSP00000428935
ENST00000523250
E5RFE0 [Direct mapping]
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
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Predicted intracellular proteins
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 195 aa
21.4 kDa 		No 0
DHDH-004
ENSP00000428672
ENST00000522614
E5RGT8 [Direct mapping]
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
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Predicted intracellular proteins
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 242 aa
26.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.