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MAP4K1

CANCER ATLAS

Gene description

 Mitogen-activated protein kinase kinase kinase kinase 1

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007419
CAB007754

GENE INFORMATION

Gene name

 MAP4K1 (HGNC Symbol)

Synonyms

 HPK1

Description

 Mitogen-activated protein kinase kinase kinase kinase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 38587641 - 38618882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104814 (version 83.38)

Entrez gene

 11184

UniProt

 Q92918 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92918

Antibodypedia

 MAP4K1 antibodies

PROTEIN BROWSER
MAP4K1-001
MAP4K1-002
MAP4K1-003
MAP4K1-004
MAP4K1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP4K1-001
ENSP00000380066
ENST00000396857
Q92918 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007257 [activation of JUN kinase activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
Show all
 821 aa
90.4 kDa 		No 0
MAP4K1-002
ENSP00000465039
ENST00000591517
Q92918 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000185 [activation of MAPKKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007257 [activation of JUN kinase activity]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0008349 [MAP kinase kinase kinase kinase activity]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
Show all
 833 aa
91.3 kDa 		No 0
MAP4K1-003
ENSP00000468164
ENST00000589130
K7ER95 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 817 aa
90 kDa 		No 0
MAP4K1-004
ENSP00000465774
ENST00000586296
K7EKT6 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 395 aa
44.1 kDa 		No 0
MAP4K1-006
ENSP00000465303
ENST00000591921
K7EJS6 [Direct mapping]
Mitogen-activated protein kinase kinase kinase kinase 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0007346 [regulation of mitotic cell cycle]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 525 aa
57 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.