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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CGB

Gene description

Chorionic gonadotropin, beta polypeptide

Protein class

Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (placenta)
GTEx:Not detected

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in placental trophoblasts.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 4 antibodies.
HPA038925 , HPA038934 , CAB000042 , CAB010884
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

CGB (HGNC Symbol)

Synonyms

CGB3

Description

Chorionic gonadotropin, beta polypeptide (HGNC Symbol)

Entrez gene summary

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

49022869 - 49024333

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104827 (version 83.38)

Entrez gene

1082

UniProt

P01233 (UniProt - Evidence at protein level)

neXtProt

NX_P01233

Antibodypedia

CGB antibodies

PROTEIN BROWSER

CGB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CGB-001
ENSP00000349954
ENST00000357383
P01233 [Direct mapping]
Choriogonadotropin subunit beta
A0A0F7RQP8 [Target identity:100%; Query identity:100%]
Chorionic gonadotropin beta subunit 3; Chorionic gonadotropin beta subunit 4
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0005179 [hormone activity]
GO:0005576 [extracellular region]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007292 [female gamete generation]
GO:0016486 [peptide hormone processing]
GO:0044267 [cellular protein metabolic process]
Show all
165 aa
17.7 kDa
Yes 0

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