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PPP1R13L

GENERAL INFORMATION

Gene name

 PPP1R13L

Gene description

 Protein phosphatase 1, regulatory subunit 13 like

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types, including skin.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA041231 , HPA059883 , CAB005016
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPP1R13L (HGNC Symbol)

Synonyms

 IASPP, RAI

Description

 Protein phosphatase 1, regulatory subunit 13 like (HGNC Symbol)

Entrez gene summary

 IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 45379634 - 45406349

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104881 (version 83.38)

Entrez gene

 10848

UniProt

 Q8WUF5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WUF5

Antibodypedia

 PPP1R13L antibodies

PROTEIN BROWSER
PPP1R13L-001
PPP1R13L-002
PPP1R13L-005
PPP1R13L-006
PPP1R13L-008
PPP1R13L-009
PPP1R13L-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R13L-001
ENSP00000354218
ENST00000360957
Q8WUF5 [Direct mapping]
RelA-associated inhibitor
A0A024R0Q5 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 13 like, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008134 [transcription factor binding]
GO:0030054 [cell junction]
GO:0042802 [identical protein binding]
GO:0045171 [intercellular bridge]
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 828 aa
89.1 kDa 		No 0
PPP1R13L-002
ENSP00000403902
ENST00000418234
Q8WUF5 [Direct mapping]
RelA-associated inhibitor
A0A024R0Q5 [Target identity:100%; Query identity:100%]
Protein phosphatase 1, regulatory (Inhibitor) subunit 13 like, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003229 [ventricular cardiac muscle tissue development]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008134 [transcription factor binding]
GO:0009791 [post-embryonic development]
GO:0030054 [cell junction]
GO:0031076 [embryonic camera-type eye development]
GO:0035264 [multicellular organism growth]
GO:0042633 [hair cycle]
GO:0042802 [identical protein binding]
GO:0045171 [intercellular bridge]
GO:0045597 [positive regulation of cell differentiation]
GO:0048871 [multicellular organismal homeostasis]
GO:0060048 [cardiac muscle contraction]
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 828 aa
89.1 kDa 		No 0
PPP1R13L-005
ENSP00000466730
ENST00000593226
K7EN03 [Direct mapping]
RelA-associated inhibitor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008134 [transcription factor binding]
GO:0030054 [cell junction]
GO:0045171 [intercellular bridge]
Show all
 128 aa
13.9 kDa 		No 0
PPP1R13L-006
ENSP00000467471
ENST00000592134
K7EPP1 [Direct mapping]
RelA-associated inhibitor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008134 [transcription factor binding]
Show all
 60 aa
6.7 kDa 		No 0
PPP1R13L-008
ENSP00000466939
ENST00000591986
K7ENG6 [Direct mapping]
RelA-associated inhibitor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 29 aa
3.1 kDa 		No 0
PPP1R13L-009
ENSP00000466555
ENST00000589371
K7EML6 [Direct mapping]
RelA-associated inhibitor
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 90 aa
9.7 kDa 		No 0
PPP1R13L-201
ENSP00000478646
ENST00000612351
A0A087WUG2 [Direct mapping]
RelA-associated inhibitor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0008134 [transcription factor binding]
Show all
 348 aa
38 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.