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KLC3

CANCER ATLAS

Gene description

 Kinesin light chain 3

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052797
HPA056508

GENE INFORMATION

Gene name

 KLC3 (HGNC Symbol)

Synonyms

 KLC2L, KLCt, KNS2B

Description

 Kinesin light chain 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 45333434 - 45351520

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104892 (version 83.38)

Entrez gene

 147700

UniProt

 Q6P597 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P597

Antibodypedia

 KLC3 antibodies

PROTEIN BROWSER
KLC3-001
KLC3-002
KLC3-004
KLC3-005
KLC3-006
KLC3-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLC3-001
ENSP00000375810
ENST00000391946
Q6P597 [Direct mapping]
Kinesin light chain 3
A0A024R0V3 [Target identity:100%; Query identity:100%]
Kinesin light chain 3, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0008017 [microtubule binding]
GO:0008088 [axon cargo transport]
GO:0008152 [metabolic process]
GO:0019894 [kinesin binding]
GO:0031514 [motile cilium]
GO:0035253 [ciliary rootlet]
GO:0043005 [neuron projection]
Show all
 504 aa
55.4 kDa 		No 0
KLC3-002
ENSP00000436019
ENST00000470402
Q6P597 [Direct mapping]
Kinesin light chain 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0008152 [metabolic process]
Show all
 518 aa
56.8 kDa 		No 0
KLC3-004
ENSP00000466067
ENST00000585434
Q6P597 [Direct mapping]
Kinesin light chain 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005871 [kinesin complex]
GO:0005874 [microtubule]
GO:0008152 [metabolic process]
Show all
 503 aa
55.2 kDa 		No 0
KLC3-005
ENSP00000465950
ENST00000589373
K7EL76 [Direct mapping]
Kinesin light chain 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005871 [kinesin complex]
GO:0008152 [metabolic process]
Show all
 397 aa
43.9 kDa 		No 0
KLC3-006
ENSP00000466974
ENST00000589837
K7ENJ3 [Direct mapping]
Kinesin light chain 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005871 [kinesin complex]
GO:0008152 [metabolic process]
Show all
 297 aa
32.9 kDa 		No 0
KLC3-007
ENSP00000466168
ENST00000590063
K7ELP9 [Direct mapping]
Kinesin light chain 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 157 aa
17.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.