Cell atlas - KLC3 - The Human Protein Atlas

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KLC3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol
	Nucleoplasm

Human cell
	Actin Filaments
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	KLC3
Gene description	Kinesin light chain 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the actin filaments. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (A-431, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (approved)
Additional location	In addition localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056508
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the actin filaments. In addition localized to the cytosol & nucleoplasm.

Main location

Actin filaments (approved)

Additional location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056508	A-431	Nucleoplasm
			Actin filaments
			Cytosol
	HPA056508	MCF7	No staining
	HPA056508	U-2 OS	Actin filaments

GENE INFORMATION
Gene name	KLC3 (HGNC Symbol)
Synonyms	KLC2L, KLCt, KNS2B
Description	Kinesin light chain 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	45333434 - 45351520
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104892 (version 83.38)
Entrez gene	147700
UniProt	Q6P597 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P597
Antibodypedia	KLC3 antibodies

PROTEIN BROWSER

KLC3-001	KLC3-002	KLC3-004	KLC3-005	KLC3-006	KLC3-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLC3-001 ENSP00000375810 ENST00000391946	Q6P597 [Direct mapping] Kinesin light chain 3 A0A024R0V3 [Target identity:100%; Query identity:100%] Kinesin light chain 3, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0008088 [axon cargo transport] GO:0008152 [metabolic process] GO:0019894 [kinesin binding] GO:0031514 [motile cilium] GO:0035253 [ciliary rootlet] GO:0043005 [neuron projection] Show all	504 aa 55.4 kDa	No	0
KLC3-002 ENSP00000436019 ENST00000470402	Q6P597 [Direct mapping] Kinesin light chain 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0008152 [metabolic process] Show all	518 aa 56.8 kDa	No	0
KLC3-004 ENSP00000466067 ENST00000585434	Q6P597 [Direct mapping] Kinesin light chain 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005871 [kinesin complex] GO:0005874 [microtubule] GO:0008152 [metabolic process] Show all	503 aa 55.2 kDa	No	0
KLC3-005 ENSP00000465950 ENST00000589373	K7EL76 [Direct mapping] Kinesin light chain 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005871 [kinesin complex] GO:0008152 [metabolic process] Show all	397 aa 43.9 kDa	No	0
KLC3-006 ENSP00000466974 ENST00000589837	K7ENJ3 [Direct mapping] Kinesin light chain 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003777 [microtubule motor activity] GO:0005515 [protein binding] GO:0005871 [kinesin complex] GO:0008152 [metabolic process] Show all	297 aa 32.9 kDa	No	0
KLC3-007 ENSP00000466168 ENST00000590063	K7ELP9 [Direct mapping] Kinesin light chain 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.