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CLEC4M

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GENERAL INFORMATION

Gene name

 CLEC4M

Gene description

 C-type lectin domain family 4, member M

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CLEC4M (HGNC Symbol)

Synonyms

 CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, LSIGN

Description

 C-type lectin domain family 4, member M (HGNC Symbol)

Entrez gene summary

 This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 7763149 - 7769605

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104938 (version 83.38)

Entrez gene

 10332

UniProt

 Q9H2X3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2X3

Antibodypedia

 CLEC4M antibodies

PROTEIN BROWSER
CLEC4M-001
CLEC4M-003
CLEC4M-004
CLEC4M-005
CLEC4M-006
CLEC4M-008
CLEC4M-201
CLEC4M-202
CLEC4M-203
CLEC4M-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLEC4M-001
ENSP00000316228
ENST00000327325
Q9H2X3 [Direct mapping]
C-type lectin domain family 4 member M
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006897 [endocytosis]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009988 [cell-cell recognition]
GO:0010468 [regulation of gene expression]
GO:0016020 [membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030193 [regulation of blood coagulation]
GO:0030246 [carbohydrate binding]
GO:0030369 [ICAM-3 receptor activity]
GO:0035556 [intracellular signal transduction]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0048306 [calcium-dependent protein binding]
GO:0075733 [intracellular transport of virus]
Show all
 399 aa
45.3 kDa 		No 1
CLEC4M-003
ENSP00000470137
ENST00000596707
M0QYX2 [Direct mapping]
C-type lectin domain family 4 member M
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 332 aa
38 kDa 		No 0
CLEC4M-004
ENSP00000471125
ENST00000596363
Q9H2X3 [Direct mapping]
C-type lectin domain family 4 member M
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006897 [endocytosis]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009988 [cell-cell recognition]
GO:0010468 [regulation of gene expression]
GO:0016020 [membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030193 [regulation of blood coagulation]
GO:0030246 [carbohydrate binding]
GO:0030369 [ICAM-3 receptor activity]
GO:0035556 [intracellular signal transduction]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0048306 [calcium-dependent protein binding]
GO:0075733 [intracellular transport of virus]
Show all
 296 aa
33.5 kDa 		No 0
CLEC4M-005
ENSP00000471132
ENST00000597522
Q9H2X3 [Direct mapping]
C-type lectin domain family 4 member M
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006897 [endocytosis]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009988 [cell-cell recognition]
GO:0010468 [regulation of gene expression]
GO:0016020 [membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030193 [regulation of blood coagulation]
GO:0030246 [carbohydrate binding]
GO:0030369 [ICAM-3 receptor activity]
GO:0035556 [intracellular signal transduction]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0048306 [calcium-dependent protein binding]
GO:0075733 [intracellular transport of virus]
Show all
 232 aa
26.3 kDa 		No 1
CLEC4M-006
ENSP00000470132
ENST00000595496
Q9H2X3 [Direct mapping]
C-type lectin domain family 4 member M
Show all
CD markers
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006897 [endocytosis]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009988 [cell-cell recognition]
GO:0010468 [regulation of gene expression]
GO:0016020 [membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030193 [regulation of blood coagulation]
GO:0030246 [carbohydrate binding]
GO:0030369 [ICAM-3 receptor activity]
GO:0035556 [intracellular signal transduction]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0048306 [calcium-dependent protein binding]
GO:0075733 [intracellular transport of virus]
Show all
 263 aa
30.1 kDa 		No 0
CLEC4M-008
ENSP00000470286
ENST00000595751
M0QZ42 [Direct mapping]
C-type lectin domain family 4 member M
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 282 aa
32.2 kDa 		No 0
CLEC4M-201
ENSP00000248228
ENST00000248228
Q9H2X3 [Direct mapping]
C-type lectin domain family 4 member M
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006897 [endocytosis]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009988 [cell-cell recognition]
GO:0010468 [regulation of gene expression]
GO:0016020 [membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030193 [regulation of blood coagulation]
GO:0030246 [carbohydrate binding]
GO:0030369 [ICAM-3 receptor activity]
GO:0035556 [intracellular signal transduction]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0048306 [calcium-dependent protein binding]
GO:0075733 [intracellular transport of virus]
Show all
 376 aa
42.7 kDa 		No 1
CLEC4M-202
ENSP00000335228
ENST00000334806
H7BXU4 [Direct mapping]
C-type lectin domain family 4 member M
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 348 aa
39.5 kDa 		No 0
CLEC4M-203
ENSP00000351954
ENST00000359059
Q9H2X3 [Direct mapping]
C-type lectin domain family 4 member M
Show all
CD markers
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0006897 [endocytosis]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0009988 [cell-cell recognition]
GO:0010468 [regulation of gene expression]
GO:0016020 [membrane]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019062 [virion attachment to host cell]
GO:0019079 [viral genome replication]
GO:0019882 [antigen processing and presentation]
GO:0030193 [regulation of blood coagulation]
GO:0030246 [carbohydrate binding]
GO:0030369 [ICAM-3 receptor activity]
GO:0035556 [intracellular signal transduction]
GO:0042605 [peptide antigen binding]
GO:0045087 [innate immune response]
GO:0046718 [viral entry into host cell]
GO:0046790 [virion binding]
GO:0046872 [metal ion binding]
GO:0046968 [peptide antigen transport]
GO:0048306 [calcium-dependent protein binding]
GO:0075733 [intracellular transport of virus]
Show all
 332 aa
38 kDa 		No 0
CLEC4M-204
ENSP00000377680
ENST00000394122
E7ENS9 [Direct mapping]
C-type lectin domain family 4 member M
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
 387 aa
44.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.