Expression of SLC1A6 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041505	HPA044066

GENE INFORMATION
Gene name	SLC1A6 (HGNC Symbol)
Synonyms	EAAT4
Description	Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	14950034 - 15022990
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105143 (version 83.38)
Entrez gene	6511
UniProt	P48664 (UniProt - Evidence at transcript level)
neXtProt	NX_P48664
Antibodypedia	SLC1A6 antibodies

PROTEIN BROWSER

SLC1A6-001	SLC1A6-002	SLC1A6-003	SLC1A6-004	SLC1A6-005	SLC1A6-007	SLC1A6-008	SLC1A6-009	SLC1A6-010	SLC1A6-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC1A6-001 ENSP00000409386 ENST00000430939	E7EV13 [Direct mapping] Amino acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] Show all	500 aa 53.1 kDa	No	7
SLC1A6-002 ENSP00000221742 ENST00000221742	P48664 [Direct mapping] Excitatory amino acid transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006835 [dicarboxylic acid transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0014047 [glutamate secretion] GO:0015183 [L-aspartate transmembrane transporter activity] GO:0015810 [aspartate transport] GO:0015813 [L-glutamate transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0089711 [L-glutamate transmembrane transport] GO:0089712 [L-aspartate transmembrane transport] Show all	564 aa 61.6 kDa	No	>9
SLC1A6-003 ENSP00000471781 ENST00000598504	P48664 [Direct mapping] Excitatory amino acid transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006835 [dicarboxylic acid transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0014047 [glutamate secretion] GO:0015183 [L-aspartate transmembrane transporter activity] GO:0015810 [aspartate transport] GO:0015813 [L-glutamate transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] GO:0089712 [L-aspartate transmembrane transport] Show all	312 aa 34.8 kDa	No	4
SLC1A6-004 ENSP00000446175 ENST00000544886	P48664 [Direct mapping] Excitatory amino acid transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006835 [dicarboxylic acid transport] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0014047 [glutamate secretion] GO:0015183 [L-aspartate transmembrane transporter activity] GO:0015810 [aspartate transport] GO:0015813 [L-glutamate transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] GO:0089712 [L-aspartate transmembrane transport] Show all	312 aa 34.8 kDa	No	4
SLC1A6-005 ENSP00000471038 ENST00000600144	M0R063 [Direct mapping] Amino acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] Show all	486 aa 53.2 kDa	No	7
SLC1A6-007 ENSP00000472837 ENST00000599636	M0R2V7 [Direct mapping] Excitatory amino acid transporter 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		146 aa 15.1 kDa	No	0
SLC1A6-008 ENSP00000469551 ENST00000595863	M0QY32 [Direct mapping] Excitatory amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] Show all	110 aa 12.8 kDa	No	1
SLC1A6-009 ENSP00000472133 ENST00000594383	M0R1V3 [Direct mapping] Excitatory amino acid transporter 4 Show all	Predicted intracellular proteins Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] Show all	35 aa 4 kDa	No	0
SLC1A6-010 ENSP00000471129 ENST00000601761	M0R0B5 [Direct mapping] Excitatory amino acid transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] Show all	74 aa 8.6 kDa	No	1
SLC1A6-011 ENSP00000471562 ENST00000597262	M0R106 [Direct mapping] Amino acid transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0006835 [dicarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0055085 [transmembrane transport] Show all	160 aa 18.1 kDa	No	3