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AURKC

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GENERAL INFORMATION

Gene name

 AURKC

Gene description

 Aurora kinase C

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 AURKC (HGNC Symbol)

Synonyms

 ARK3, AurC, STK13

Description

 Aurora kinase C (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.43

Chromosome location (bp)

 57230802 - 57235548

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105146 (version 83.38)

Entrez gene

 6795

UniProt

 Q9UQB9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQB9

Antibodypedia

 AURKC antibodies

PROTEIN BROWSER
AURKC-001
AURKC-002
AURKC-003
AURKC-004
AURKC-005
AURKC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AURKC-001
ENSP00000302898
ENST00000302804
Q9UQB9 [Direct mapping]
Aurora kinase C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000793 [condensed chromosome]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 309 aa
35.6 kDa 		No 0
AURKC-002
ENSP00000407162
ENST00000415300
Q9UQB9 [Direct mapping]
Aurora kinase C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000793 [condensed chromosome]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 290 aa
33.7 kDa 		No 0
AURKC-003
ENSP00000469983
ENST00000599062
Q5Y191 [Direct mapping]
Aurora kinase C; Aurora-C
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051255 [spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 306 aa
35.3 kDa 		No 0
AURKC-004
ENSP00000471830
ENST00000598785
Q9UQB9 [Direct mapping]
Aurora kinase C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000793 [condensed chromosome]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 275 aa
32.2 kDa 		No 0
AURKC-005
ENSP00000469894
ENST00000594599
M0QYK8 [Direct mapping]
Aurora kinase C
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051255 [spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 137 aa
16 kDa 		No 0
AURKC-201
ENSP00000406798
ENST00000448930
A0A0A0MSY3 [Direct mapping]
Aurora kinase C
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051255 [spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 274 aa
32.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.