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AURKC

GENERAL INFORMATION

Gene name

 AURKC

Gene description

 Aurora kinase C

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA034859
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 AURKC (HGNC Symbol)

Synonyms

 ARK3, AurC, STK13

Description

 Aurora kinase C (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.43

Chromosome location (bp)

 57230802 - 57235548

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105146 (version 83.38)

Entrez gene

 6795

UniProt

 Q9UQB9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQB9

Antibodypedia

 AURKC antibodies

PROTEIN BROWSER
AURKC-001
AURKC-002
AURKC-003
AURKC-004
AURKC-005
AURKC-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AURKC-001
ENSP00000302898
ENST00000302804
Q9UQB9 [Direct mapping]
Aurora kinase C
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000793 [condensed chromosome]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 309 aa
35.6 kDa 		No 0
AURKC-002
ENSP00000407162
ENST00000415300
Q9UQB9 [Direct mapping]
Aurora kinase C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000793 [condensed chromosome]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 290 aa
33.7 kDa 		No 0
AURKC-003
ENSP00000469983
ENST00000599062
Q5Y191 [Direct mapping]
Aurora kinase C; Aurora-C
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051255 [spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 306 aa
35.3 kDa 		No 0
AURKC-004
ENSP00000471830
ENST00000598785
Q9UQB9 [Direct mapping]
Aurora kinase C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000793 [condensed chromosome]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 275 aa
32.2 kDa 		No 0
AURKC-005
ENSP00000469894
ENST00000594599
M0QYK8 [Direct mapping]
Aurora kinase C
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051255 [spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 137 aa
16 kDa 		No 0
AURKC-201
ENSP00000406798
ENST00000448930
A0A0A0MSY3 [Direct mapping]
Aurora kinase C
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0000910 [cytokinesis]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007283 [spermatogenesis]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0048599 [oocyte development]
GO:0051255 [spindle midzone assembly]
GO:0051321 [meiotic cell cycle]
Show all
 274 aa
32.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.