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Renal cancers showed moderate to strong cytoplasmic staining. Melanomas, liver, urothelial, colorectal and ovarian cancers displayed weak to moderate cytoplasmic staining. Remaining cancer tissues were in general weakly stained or negative.
Renal, endometrial, breast and colorectal cancers displayed moderate immunoreactivity in a majority of cases. Most remaining cancer tissues were weakly stained or negative.
Cancer tissues showed moderate to strong cytoplasmic and nuclear staining. Several cases of gliomas and lymphomas were weakly stained or negative.
GENE INFORMATION
Gene name
GPI (HGNC Symbol)
Synonyms
AMF, NLK
Description
Glucose-6-phosphate isomerase (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
