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Cancer tissues displayed weak to moderate membranous and cytoplasmic staining. Rare cases of colorectal, endometrial and testicular cancers were strongly stained. Gliomas, lymphomas, melanomas, skin and renal cancers along with most of the prostate and ovarian cancers were negative.
A majority of cancers showed weak to moderate cell membrane staining. Gliomas, lymphomas, skin and renal cancers were negative.
GENE INFORMATION
Gene name
TJP3 (HGNC Symbol)
Synonyms
ZO-3
Description
Tight junction protein 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
