Tissue expression of TJP3 - Summary - The Human Protein Atlas

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TJP3

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TJP3
Gene description	Tight junction protein 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (duodenum, small intestine)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (small intestine, testis)

Protein evidence

Evidence at protein level

Protein expression

Distinct cell membranous expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA053337 , CAB013244
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (duodenum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine, testis)

GENE INFORMATION
Gene name	TJP3 (HGNC Symbol)
Synonyms	ZO-3
Description	Tight junction protein 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	3708109 - 3750813
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105289 (version 83.38)
Entrez gene	27134
UniProt	O95049 (UniProt - Evidence at protein level)
neXtProt	NX_O95049
Antibodypedia	TJP3 antibodies

PROTEIN BROWSER

TJP3-001	TJP3-002	TJP3-003	TJP3-004	TJP3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TJP3-001 ENSP00000467864 ENST00000587686	O95049 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005923 [bicellular tight junction] GO:0030054 [cell junction] Show all	938 aa 103.4 kDa	No	0
TJP3-002 ENSP00000439278 ENST00000541714	O95049 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005923 [bicellular tight junction] GO:0030054 [cell junction] Show all	919 aa 101.4 kDa	No	0
TJP3-003 ENSP00000439991 ENST00000539908	O95049 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005923 [bicellular tight junction] GO:0030054 [cell junction] Show all	883 aa 97.5 kDa	No	0
TJP3-004 ENSP00000465419 ENST00000589378	O95049 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005923 [bicellular tight junction] GO:0016324 [apical plasma membrane] GO:0030054 [cell junction] GO:2000045 [regulation of G1/S transition of mitotic cell cycle] Show all	928 aa 102.4 kDa	No	0
TJP3-005 ENSP00000468641 ENST00000590545	K7ESC0 [Direct mapping] Tight junction protein ZO-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005923 [bicellular tight junction] Show all	123 aa 13.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.