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Cancer cells showed moderate to strong cytoplasmic staining. Several cases of e.g. liver, thyroid and colorectal cancers displayed strong cytoplasmic staining. Skin cancers were in general negative.
Most cancer cells showed moderate cytoplasmic immunoreactivity. A majority of colorectal, thyroid and hepatocellular carcinomas showed strong granular cytoplasmic staining. Many skin, testicular and cervical cancers were weakly stained or negative.
This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]