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CD33

GENERAL INFORMATION

Gene name

 CD33

Gene description

 CD33 molecule

Protein class

 CD markers
FDA approved drug targets
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (lymph node, spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in subsets of lymphoid and hemaotpoietic cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA035832 , CAB011442
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen)

GENE INFORMATION

Gene name

 CD33 (HGNC Symbol)

Synonyms

 FLJ00391, p67, SIGLEC-3, SIGLEC3

Description

 CD33 molecule (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q13.41

Chromosome location (bp)

 51225064 - 51243860

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105383 (version 83.38)

Entrez gene

 945

UniProt

 P20138 (UniProt - Evidence at protein level)

neXtProt

 NX_P20138

Antibodypedia

 CD33 antibodies

PROTEIN BROWSER
CD33-001
CD33-002
CD33-003
CD33-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD33-001
ENSP00000262262
ENST00000262262
P20138 [Direct mapping]
Myeloid cell surface antigen CD33
Q546G0 [Target identity:100%; Query identity:100%]
CD33 antigen (Gp67); CD33 antigen (Gp67), isoform CRA_b
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008285 [negative regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0030246 [carbohydrate binding]
GO:0050776 [regulation of immune response]
GO:0070062 [extracellular exosome]
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 364 aa
39.8 kDa 		Yes 1
CD33-002
ENSP00000410126
ENST00000421133
P20138 [Direct mapping]
Myeloid cell surface antigen CD33
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008285 [negative regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0030246 [carbohydrate binding]
GO:0050776 [regulation of immune response]
GO:0070062 [extracellular exosome]
Show all
 237 aa
25.3 kDa 		Yes 1
CD33-003
ENSP00000375673
ENST00000391796
P20138 [Direct mapping]
Myeloid cell surface antigen CD33
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008285 [negative regulation of cell proliferation]
GO:0009897 [external side of plasma membrane]
GO:0030246 [carbohydrate binding]
GO:0050776 [regulation of immune response]
GO:0070062 [extracellular exosome]
Show all
 310 aa
33.9 kDa 		Yes 1
CD33-005
ENSP00000403331
ENST00000436584
B4DF51 [Direct mapping]
Myeloid cell surface antigen CD33; cDNA FLJ50122, highly similar to Myeloid cell surface antigen CD33
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 212 aa
22.3 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.