Expression of PRPF31 in cancer - Summary

CANCER ATLAS

Gene description

Pre-mRNA processing factor 31

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041939

GENE INFORMATION
Gene name	PRPF31 (HGNC Symbol)
Synonyms	hPrp31, NY-BR-99, PRP31, RP11, SNRNP61
Description	Pre-mRNA processing factor 31 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	54115410 - 54131719
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105618 (version 83.38)
Entrez gene	26121
UniProt	Q8WWY3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWY3
Antibodypedia	PRPF31 antibodies

PROTEIN BROWSER

PRPF31-001	PRPF31-003	PRPF31-005	PRPF31-006	PRPF31-009	PRPF31-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRPF31-001 ENSP00000324122 ENST00000321030	Q8WWY3 [Direct mapping] U4/U6 small nuclear ribonucleoprotein Prp31 F1T0A5 [Target identity:100%; Query identity:100%] PRP31 pre-mRNA processing factor 31 homolog (Yeast), isoform CRA_a; U4/U6 small nuclear ribonucleoprotein Prp31 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000244 [spliceosomal tri-snRNP complex assembly] GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005684 [U2-type spliceosomal complex] GO:0005687 [U4 snRNP] GO:0005690 [U4atac snRNP] GO:0015030 [Cajal body] GO:0016607 [nuclear speck] GO:0030621 [U4 snRNA binding] GO:0030622 [U4atac snRNA binding] GO:0043021 [ribonucleoprotein complex binding] GO:0044822 [poly(A) RNA binding] GO:0046540 [U4/U6 x U5 tri-snRNP complex] GO:0070990 [snRNP binding] GO:0071011 [precatalytic spliceosome] GO:0071339 [MLL1 complex] Show all	499 aa 55.5 kDa	No	0
PRPF31-003 ENSP00000375635 ENST00000391755	E7EVX8 [Direct mapping] U4/U6 small nuclear ribonucleoprotein Prp31 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	493 aa 54.8 kDa	No	0
PRPF31-005 ENSP00000395894 ENST00000445811	E7EN72 [Direct mapping] U4/U6 small nuclear ribonucleoprotein Prp31 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000244 [spliceosomal tri-snRNP complex assembly] GO:0005634 [nucleus] GO:0046540 [U4/U6 x U5 tri-snRNP complex] Show all	284 aa 31.4 kDa	No	0
PRPF31-006 ENSP00000408980 ENST00000445124	E7ESX0 [Direct mapping] U4/U6 small nuclear ribonucleoprotein Prp31 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000244 [spliceosomal tri-snRNP complex assembly] GO:0005634 [nucleus] GO:0046540 [U4/U6 x U5 tri-snRNP complex] Show all	276 aa 30.6 kDa	No	0
PRPF31-009 ENSP00000395089 ENST00000447810	E7EU94 [Direct mapping] U4/U6 small nuclear ribonucleoprotein Prp31 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000244 [spliceosomal tri-snRNP complex assembly] GO:0005634 [nucleus] GO:0046540 [U4/U6 x U5 tri-snRNP complex] Show all	261 aa 28.9 kDa	No	0
PRPF31-201 ENSP00000405166 ENST00000419967	Q8WWY3 [Direct mapping] U4/U6 small nuclear ribonucleoprotein Prp31 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000244 [spliceosomal tri-snRNP complex assembly] GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005684 [U2-type spliceosomal complex] GO:0005687 [U4 snRNP] GO:0005690 [U4atac snRNP] GO:0015030 [Cajal body] GO:0016607 [nuclear speck] GO:0030621 [U4 snRNA binding] GO:0030622 [U4atac snRNA binding] GO:0043021 [ribonucleoprotein complex binding] GO:0044822 [poly(A) RNA binding] GO:0046540 [U4/U6 x U5 tri-snRNP complex] GO:0070990 [snRNP binding] GO:0071011 [precatalytic spliceosome] GO:0071339 [MLL1 complex] Show all	491 aa 54.9 kDa	No	0