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Most cancer tissues displayed weak to moderate nuclear positivity. Lymphomas, breast, liver, renal cancers along with several cases of prostate cancers were negative.
Malignant tissues were mostly negative. A few cases of gastric cancers displayed strong cytoplasmic staining. Moderate cytoplasmic positivity was observed in a few cases of ovarian, cervical and lung cancers.
GENE INFORMATION
Gene name
SLC5A5 (HGNC Symbol)
Synonyms
NIS
Description
Solute carrier family 5 (sodium/iodide cotransporter), member 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]