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SLC5A5

GENERAL INFORMATION

Gene name

 SLC5A5

Gene description

 Solute carrier family 5 (sodium/iodide cotransporter), member 5

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (stomach, salivary gland, thyroid gland)
GTEx:Tissue enhanced (stomach, thyroid gland)
FANTOM5:Tissue enriched (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic and membranous expression, most abundant in thyroid gland, salivary ducts and stomach.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA049055 , CAB022364
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach, salivary gland, thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach, thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION

Gene name

 SLC5A5 (HGNC Symbol)

Synonyms

 NIS

Description

 Solute carrier family 5 (sodium/iodide cotransporter), member 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 17871973 - 17895174

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105641 (version 83.38)

Entrez gene

 6528

UniProt

 Q92911 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92911

Antibodypedia

 SLC5A5 antibodies

PROTEIN BROWSER
SLC5A5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC5A5-001
ENSP00000222248
ENST00000222248
Q92911 [Direct mapping]
Sodium/iodide cotransporter
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
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GO:0005215 [transporter activity]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006590 [thyroid hormone generation]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0008507 [sodium:iodide symporter activity]
GO:0015111 [iodide transmembrane transporter activity]
GO:0015293 [symporter activity]
GO:0015705 [iodide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035725 [sodium ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
GO:0098656 [anion transmembrane transport]
GO:1903561 [extracellular vesicle]
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 643 aa
68.7 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.