Expression of ATP4A in cancer - Summary

CANCER ATLAS

Gene description

ATPase, H+/K+ exchanging, alpha polypeptide

Protein class

Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039154

GENE INFORMATION
Gene name	ATP4A (HGNC Symbol)
Synonyms	ATP6A
Description	ATPase, H+/K+ exchanging, alpha polypeptide (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35550043 - 35563658
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105675 (version 83.38)
Entrez gene	495
UniProt	P20648 (UniProt - Evidence at transcript level)
neXtProt	NX_P20648
Antibodypedia	ATP4A antibodies

PROTEIN BROWSER

ATP4A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP4A-001 ENSP00000262623 ENST00000262623	P20648 [Direct mapping] Potassium-transporting ATPase alpha chain 1 Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0005391 [sodium:potassium-exchanging ATPase activity] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006813 [potassium ion transport] GO:0006814 [sodium ion transport] GO:0006883 [cellular sodium ion homeostasis] GO:0008152 [metabolic process] GO:0008900 [hydrogen:potassium-exchanging ATPase activity] GO:0010107 [potassium ion import] GO:0010155 [regulation of proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030007 [cellular potassium ion homeostasis] GO:0034220 [ion transmembrane transport] GO:0036376 [sodium ion export from cell] GO:0042493 [response to drug] GO:0043231 [intracellular membrane-bounded organelle] GO:0045851 [pH reduction] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] Show all	1035 aa 114.1 kDa	No	>9