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ATP4A

GENERAL INFORMATION

Gene name

 ATP4A

Gene description

 ATPase, H+/K+ exchanging, alpha polypeptide

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (stomach)
GTEx:Tissue enriched (stomach)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in gastric parietal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA039154
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 ATP4A (HGNC Symbol)

Synonyms

 ATP6A

Description

 ATPase, H+/K+ exchanging, alpha polypeptide (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.12

Chromosome location (bp)

 35550043 - 35563658

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105675 (version 83.38)

Entrez gene

 495

UniProt

 P20648 (UniProt - Evidence at transcript level)

neXtProt

 NX_P20648

Antibodypedia

 ATP4A antibodies

PROTEIN BROWSER
ATP4A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP4A-001
ENSP00000262623
ENST00000262623
P20648 [Direct mapping]
Potassium-transporting ATPase alpha chain 1
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0008152 [metabolic process]
GO:0008900 [hydrogen:potassium-exchanging ATPase activity]
GO:0010107 [potassium ion import]
GO:0010155 [regulation of proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030007 [cellular potassium ion homeostasis]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0042493 [response to drug]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045851 [pH reduction]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0055085 [transmembrane transport]
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 1035 aa
114.1 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.