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PBX4

GENERAL INFORMATION

Gene name

 PBX4

Gene description

 Pre-B-cell leukemia homeobox 4

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis, thyroid gland)
GTEx:Tissue enhanced (thyroid gland)
FANTOM5:Tissue enhanced (testis, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in a subset of cells in seminiferus ducts in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA049859
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis, thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis, thyroid gland)

GENE INFORMATION

Gene name

 PBX4

Synonyms

Description

 Pre-B-cell leukemia homeobox 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 19561707 - 19618916

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105717 (version 83.38)

Entrez gene

 80714

UniProt

 Q9BYU1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYU1

Antibodypedia

 PBX4 antibodies

PROTEIN BROWSER
PBX4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PBX4-001
ENSP00000251203
ENST00000251203
Q9BYU1 [Direct mapping]
Pre-B-cell leukemia transcription factor 4
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
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GO:0001741 [XY body]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
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 374 aa
40.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.