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Most cancer tissues were weakly stained or negative. Moderate to strong cytoplasmic positivity was observed in a few cases of most cancers. Several cases showed additional nuclear immunoreactivity.
Most cancer tissues were negative. Weak to moderate cytoplasmic immunoreactivity was observed in lymphomas, pancreatic cancers and ovarian cancers.
GENE INFORMATION
Gene name
CDK6 (HGNC Symbol)
Synonyms
PLSTIRE
Description
Cyclin-dependent kinase 6 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0001726 [ruffle] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0003323 [type B pancreatic cell development] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007050 [cell cycle arrest] GO:0007219 [Notch signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0009615 [response to virus] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0014002 [astrocyte development] GO:0016301 [kinase activity] GO:0021542 [dentate gyrus development] GO:0021670 [lateral ventricle development] GO:0030097 [hemopoiesis] GO:0030332 [cyclin binding] GO:0033077 [T cell differentiation in thymus] GO:0042063 [gliogenesis] GO:0043697 [cell dedifferentiation] GO:0045596 [negative regulation of cell differentiation] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045646 [regulation of erythrocyte differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045786 [negative regulation of cell cycle] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048699 [generation of neurons] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051301 [cell division] GO:0060218 [hematopoietic stem cell differentiation] GO:2000145 [regulation of cell motility] GO:2000773 [negative regulation of cellular senescence]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0001726 [ruffle] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0003323 [type B pancreatic cell development] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007050 [cell cycle arrest] GO:0008285 [negative regulation of cell proliferation] GO:0009615 [response to virus] GO:0010468 [regulation of gene expression] GO:0014002 [astrocyte development] GO:0021542 [dentate gyrus development] GO:0021670 [lateral ventricle development] GO:0030332 [cyclin binding] GO:0042063 [gliogenesis] GO:0043697 [cell dedifferentiation] GO:0045596 [negative regulation of cell differentiation] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045646 [regulation of erythrocyte differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045786 [negative regulation of cell cycle] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048699 [generation of neurons] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051301 [cell division] GO:2000145 [regulation of cell motility] GO:2000773 [negative regulation of cellular senescence]
