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TFPI2

GENERAL INFORMATION

Gene name

 TFPI2

Gene description

 Tissue factor pathway inhibitor 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Tissue enhanced (ovary, adrenal gland)
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in placental trophoblasts.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA049158 , CAB010142
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary, adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 TFPI2 (HGNC Symbol)

Synonyms

 PP5, REF1, TFPI-2

Description

 Tissue factor pathway inhibitor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 93885397 - 93890991

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105825 (version 83.38)

Entrez gene

 7980

UniProt

 P48307 (UniProt - Evidence at protein level)

neXtProt

 NX_P48307

Antibodypedia

 TFPI2 antibodies

PROTEIN BROWSER
TFPI2-001
TFPI2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TFPI2-001
ENSP00000222543
ENST00000222543
P48307 [Direct mapping]
Tissue factor pathway inhibitor 2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005201 [extracellular matrix structural constituent]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005634 [nucleus]
GO:0007596 [blood coagulation]
GO:0010951 [negative regulation of endopeptidase activity]
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 235 aa
26.9 kDa 		Yes 0
TFPI2-003
ENSP00000416370
ENST00000451238
H7C4A3 [Direct mapping]
Tissue factor pathway inhibitor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0010951 [negative regulation of endopeptidase activity]
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 107 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.