Expression of CBLL1 in cancer - Summary

CANCER ATLAS

Gene description

Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA021773	HPA026699

GENE INFORMATION
Gene name	CBLL1 (HGNC Symbol)
Synonyms	FLJ23109, HAKAI, RNF188
Description	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]
Chromosome	7
Cytoband	q22.3
Chromosome location (bp)	107743697 - 107761667
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105879 (version 83.38)
Entrez gene	79872
UniProt	Q75N03 (UniProt - Evidence at protein level)
neXtProt	NX_Q75N03
Antibodypedia	CBLL1 antibodies

PROTEIN BROWSER

CBLL1-004	CBLL1-006	CBLL1-009	CBLL1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CBLL1-004 ENSP00000401277 ENST00000440859	Q75N03 [Direct mapping] E3 ubiquitin-protein ligase Hakai Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0007162 [negative regulation of cell adhesion] GO:0008270 [zinc ion binding] GO:0016337 [single organismal cell-cell adhesion] GO:0016567 [protein ubiquitination] GO:0016607 [nuclear speck] GO:0016874 [ligase activity] GO:0030155 [regulation of cell adhesion] GO:0030335 [positive regulation of cell migration] GO:0042802 [identical protein binding] GO:0045807 [positive regulation of endocytosis] GO:0061630 [ubiquitin protein ligase activity] Show all	491 aa 54.5 kDa	No	0
CBLL1-006 ENSP00000410615 ENST00000420796	C9J2P9 [Direct mapping] E3 ubiquitin-protein ligase Hakai Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0030155 [regulation of cell adhesion] GO:0061630 [ubiquitin protein ligase activity] Show all	323 aa 36.4 kDa	No	0
CBLL1-009 ENSP00000401175 ENST00000415884	C9K074 [Direct mapping] E3 ubiquitin-protein ligase Hakai Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016567 [protein ubiquitination] GO:0030155 [regulation of cell adhesion] GO:0061630 [ubiquitin protein ligase activity] Show all	123 aa 14 kDa	No	0
CBLL1-014 ENSP00000222597 ENST00000222597	Q75N03 [Direct mapping] E3 ubiquitin-protein ligase Hakai Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0007162 [negative regulation of cell adhesion] GO:0008270 [zinc ion binding] GO:0016337 [single organismal cell-cell adhesion] GO:0016567 [protein ubiquitination] GO:0016607 [nuclear speck] GO:0016874 [ligase activity] GO:0030155 [regulation of cell adhesion] GO:0030335 [positive regulation of cell migration] GO:0045807 [positive regulation of endocytosis] GO:0061630 [ubiquitin protein ligase activity] Show all	490 aa 54.4 kDa	No	0