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CBLL1

GENERAL INFORMATION

Gene name

 CBLL1

Gene description

 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA021773 , HPA026699
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CBLL1 (HGNC Symbol)

Synonyms

 FLJ23109, HAKAI, RNF188

Description

 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]

Chromosome

 7

Cytoband

 q22.3

Chromosome location (bp)

 107743697 - 107761667

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105879 (version 83.38)

Entrez gene

 79872

UniProt

 Q75N03 (UniProt - Evidence at protein level)

neXtProt

 NX_Q75N03

Antibodypedia

 CBLL1 antibodies

PROTEIN BROWSER
CBLL1-004
CBLL1-006
CBLL1-009
CBLL1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBLL1-004
ENSP00000401277
ENST00000440859
Q75N03 [Direct mapping]
E3 ubiquitin-protein ligase Hakai
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0007162 [negative regulation of cell adhesion]
GO:0008270 [zinc ion binding]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0042802 [identical protein binding]
GO:0045807 [positive regulation of endocytosis]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 491 aa
54.5 kDa 		No 0
CBLL1-006
ENSP00000410615
ENST00000420796
C9J2P9 [Direct mapping]
E3 ubiquitin-protein ligase Hakai
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0030155 [regulation of cell adhesion]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 323 aa
36.4 kDa 		No 0
CBLL1-009
ENSP00000401175
ENST00000415884
C9K074 [Direct mapping]
E3 ubiquitin-protein ligase Hakai
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016567 [protein ubiquitination]
GO:0030155 [regulation of cell adhesion]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 123 aa
14 kDa 		No 0
CBLL1-014
ENSP00000222597
ENST00000222597
Q75N03 [Direct mapping]
E3 ubiquitin-protein ligase Hakai
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0007162 [negative regulation of cell adhesion]
GO:0008270 [zinc ion binding]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016567 [protein ubiquitination]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0045807 [positive regulation of endocytosis]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 490 aa
54.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.